PASS Pro 1.41 SAR Base Leave-One-Out Cross-Validation (MEP = Mean Error of Prediction) Training set No Activity size MEP, % 1 2,3-Oxidosqualene-lanosterol cyclase inhibitor 17 19.429 2 3 Hydroxyanthranilate oxygenase inhibitor 4 26.940 3 5 Alpha reductase inhibitor 157 7.126 4 5 Hydroxytryptamine 1 agonist 328 6.564 5 5 Hydroxytryptamine 1 antagonist 128 8.930 6 5 Hydroxytryptamine 1A agonist 188 7.530 7 5 Hydroxytryptamine 1A antagonist 85 9.797 8 5 Hydroxytryptamine 1B agonist 18 11.071 9 5 Hydroxytryptamine 1D agonist 120 5.892 10 5 Hydroxytryptamine 1D antagonist 47 9.471 11 5 Hydroxytryptamine 1F agonist 8 7.023 12 5 Hydroxytryptamine 2 agonist 14 26.789 13 5 Hydroxytryptamine 2 antagonist 204 11.475 14 5 Hydroxytryptamine 2A antagonist 69 13.569 15 5 Hydroxytryptamine 2B antagonist 22 15.741 16 5 Hydroxytryptamine 2C agonist 11 29.625 17 5 Hydroxytryptamine 2C antagonist 47 13.480 18 5 Hydroxytryptamine 3 agonist 15 20.016 19 5 Hydroxytryptamine 3 antagonist 210 5.802 20 5 Hydroxytryptamine 4 agonist 49 4.907 21 5 Hydroxytryptamine 4 antagonist 41 7.381 22 5 Hydroxytryptamine agonist 432 8.320 23 5 Hydroxytryptamine antagonist 748 13.799 24 5 Hydroxytryptamine release stimulant 8 28.014 25 5 Hydroxytryptamine uptake inhibitor 99 11.953 26 ADP ribosyl transferase inhibitor 5 23.673 27 AMPA receptor agonist 14 9.804 28 AMPA receptor antagonist 120 7.303 29 Acetyl CoA transferase inhibitor 259 7.864 30 Acetylcholine M1 receptor agonist 161 8.874 31 Acetylcholine M2 receptor antagonist 14 16.752 32 Acetylcholine M3 receptor antagonist 32 16.748 33 Acetylcholine agonist 309 14.714 34 Acetylcholine antagonist 710 15.155 35 Acetylcholine muscarinic agonist 189 11.457 36 Acetylcholine muscarinic antagonist 420 15.063 37 Acetylcholine neuromuscular blocking agent 22 5.358 38 Acetylcholine nicotinic agonist 75 16.132 39 Acetylcholine nicotinic antagonist 286 13.349 40 Acetylcholine release stimulant 17 28.554 41 Acetylcholinesterase inhibitor 190 12.197 42 Acute neurologic disorders treatment 840 22.699 43 Adenosine A1 receptor agonist 24 4.103 44 Adenosine A1 receptor antagonist 47 8.274 45 Adenosine A2 receptor agonist 23 2.498 46 Adenosine A2 receptor antagonist 33 5.675 47 Adenosine A2a receptor agonist 3 12.628 48 Adenosine A2a receptor antagonist 11 6.172 49 Adenosine A3 receptor agonist 5 3.503 50 Adenosine A3 receptor antagonist 11 26.543 51 Adenosine deaminase inhibitor 7 4.107 52 Adenosine kinase inhibitor 12 11.078 53 Adenosine receptor agonist 50 2.421 54 Adenosine receptor antagonist 86 7.075 55 Adrenaline agonist 379 12.973 56 Adrenaline antagonist 592 13.196 57 Adrenergic transmitter uptake inhibitor 26 22.963 58 Alcohol dehydrogenase inhibitor 19 24.820 59 Aldose reductase inhibitor 171 10.026 60 Aldosterone antagonist 16 17.308 61 Alkylator 101 9.585 62 Alkylphospholipid 7 7.009 63 Alpha 1 adrenoreceptor agonist 5 22.717 64 Alpha 1 adrenoreceptor antagonist 134 9.754 65 Alpha 2 adrenoreceptor agonist 34 12.799 66 Alpha 2 adrenoreceptor antagonist 63 10.637 67 Alpha adrenoreceptor agonist 119 11.089 68 Alpha adrenoreceptor antagonist 333 13.917 69 Alpha glucosidase inhibitor 32 6.510 70 Alzheimer's disease treatment 16 30.624 71 Aminopeptidase microsomal inhibitor 6 27.269 72 Anabolic 46 14.079 73 Analeptic 91 19.595 74 Analgesic 1426 22.077 75 Analgesic, non-opioid 858 22.497 76 Analgesic, opioid 391 11.235 77 Anaphylatoxin receptor antagonist 4 22.453 78 Androgen agonist 33 7.294 79 Androgen antagonist 123 10.261 80 Anesthetic 387 16.439 81 Anesthetic general 14 18.333 82 Anesthetic inhalation 6 17.124 83 Anesthetic local 365 16.249 84 Angiogenesis inhibitor 102 24.330 85 Angiotensin AT1 receptor antagonist 169 2.048 86 Angiotensin AT2 receptor antagonist 21 9.948 87 Angiotensin II receptor antagonist 483 2.748 88 Angiotensin antagonist 483 2.748 89 Angiotensin converting enzyme inhibitor 142 5.841 90 Anorexic 91 19.113 91 Anti-Helicobacter pylori 85 19.259 92 Antiacne 215 9.834 93 Antiallergic 1673 21.900 94 Antiamebic 59 22.583 95 Antianginal 602 22.792 96 Antiarrhythmic 748 17.266 97 Antiarthritic 935 26.853 98 Antiasthmatic 12 27.730 99 Antibacterial 2681 15.346 100 Antibiotic 1581 5.747 101 Antibiotic Aminoglycoside-like 15 7.403 102 Antibiotic Anthracycline-like 51 2.246 103 Antibiotic Carbacephem-like 27 3.659 104 Antibiotic Carbapenem-like 190 0.895 105 Antibiotic Cephalosporin-like 366 1.078 106 Antibiotic Glycopeptide-like 32 2.060 107 Antibiotic Isocephem-like 8 2.786 108 Antibiotic Macrolide-like 146 2.085 109 Antibiotic Naphthyridine-like 46 2.061 110 Antibiotic Oxacephem-like 12 7.800 111 Antibiotic Oxazolidinone-like 51 2.156 112 Antibiotic Penem-like 44 2.074 113 Antibiotic Penicillin-like 31 2.399 114 Antibiotic Quinolone-like 286 0.725 115 Antibiotic Rifamycin-like 22 1.081 116 Antibiotic Tetracycline-like 7 3.835 117 Antibiotic Tribactam-like 17 2.309 118 Antibiotic Trimethoprim-like 3 4.986 119 Antibiotic beta Lactam-like 767 1.364 120 Anticataract 21 21.959 121 Anticerebroischemic 247 25.288 122 Anticholelithogenic 5 3.543 123 Anticoagulant 389 11.411 124 Anticoccidial 86 16.103 125 Anticonvulsant 922 21.914 126 Antidepressant 1037 17.756 127 Antidepressant, Imipramin-like 87 14.484 128 Antidiabetic 646 17.982 129 Antidiabetic symptomatic 219 15.529 130 Antidiuretic hormone antagonist 51 6.503 131 Antidyskinetic 15 33.766 132 Antiemetic 360 11.284 133 Antiemphysemic 132 11.739 134 Antifungal 1064 20.343 135 Antiglaucomic 257 17.294 136 Antihelmintic 338 18.902 137 Antihistaminic 167 9.223 138 Antihypercholesterolemic 144 20.689 139 Antihypertensive 2860 22.203 140 Antiinfective (HIV) 30 28.116 141 Antiinfertility, female 11 12.565 142 Antiinflammatory 1879 24.296 143 Antiinflammatory steroid 12 2.950 144 Antiinflammatory, intestinal 32 28.363 145 Antiinflammatory, pancreatic 16 27.741 146 Antiischemic 100 32.249 147 Antilipidemic 7 29.817 148 Antimalarial 186 16.967 149 Antimetabolite 218 9.868 150 Antimigraine 266 13.646 151 Antimitotic 145 8.253 152 Antimitotic Taxane-like 96 1.046 153 Antimitotic podophyllotoxin-like 30 2.091 154 Antimycobacterial 326 18.143 155 Antimycoplasmal 18 12.987 156 Antineoplastic 3862 21.378 157 Antineoplastic alkaloid 43 11.107 158 Antineoplastic antibiotic 366 10.804 159 Antineoplastic enhancer 116 20.766 160 Antiobesity 195 18.955 161 Antiosteoporotic 262 19.891 162 Antioxidant 115 15.980 163 Antiparkinsonian 381 21.469 164 Antiparkinsonian, rigidity relieving 38 23.571 165 Antiparkinsonian, tremor relieving 119 20.708 166 Antiprotozoal 588 17.345 167 Antipruritic 24 31.666 168 Antipsoriatic 383 22.591 169 Antipsychotic 991 13.830 170 Antiseptic 17 27.176 171 Antismoking 14 26.956 172 Antispirochetal 31 15.644 173 Antitoxic 70 23.660 174 Antitrichomonal 76 18.908 175 Antitrypanosomal 81 19.425 176 Antitussive 161 18.006 177 Antitussive, narcotic 34 14.311 178 Antiulcerative 509 23.016 179 Antiviral 1748 21.059 180 Antiviral (HIV) 815 16.056 181 Antiviral (hepatitis C) 7 28.086 182 Antiviral (hepatitis) 9 32.440 183 Antiviral (influenza) 6 1.620 184 Anxiolytic 1143 17.900 185 Aromatase inhibitor 98 5.957 186 Arrhythmogenic 14 31.332 187 Atherosclerosis treatment 37 33.480 188 Atrial natriuretic polypeptide agonist 8 10.820 189 Benzodiazepine agonist 76 9.181 190 Benzodiazepine agonist partial 25 14.249 191 Benzodiazepine antagonist 7 17.412 192 Benzodiazepine inverse agonist 10 8.349 193 Beta 1 adrenoreceptor agonist 34 9.986 194 Beta 1 adrenoreceptor antagonist 27 6.228 195 Beta 2 adrenoreceptor agonist 53 7.629 196 Beta 3 adrenoreceptor agonist 76 3.232 197 Beta adrenoreceptor agonist 225 8.511 198 Beta adrenoreceptor antagonist 190 8.231 199 Beta lactamase inhibitor 43 6.925 200 Bisphosphonate 51 2.815 201 Bombesin antagonist 9 5.575 202 Bone formation stimulant 40 22.994 203 Bone resorption inhibitor 92 22.978 204 Bradykinin B2 receptor antagonist 31 8.242 205 Bradykinin antagonist 53 9.146 206 Bronchodilator 454 17.236 207 CNS active muscle relaxant 104 20.451 208 Calcium agonist 10 6.616 209 Calcium channel antagonist 359 13.319 210 Calcium regulator 123 22.988 211 Calmodulin antagonist 5 20.767 212 Calpain inhibitor 14 15.854 213 Cannabinoid receptor agonist 3 21.368 214 Carbonic anhydrase inhibitor 47 2.161 215 Carcinogenic 547 14.821 216 Cardiodepressant 144 23.271 217 Cardioprotectant 17 28.343 218 Cardiotonic 1334 20.522 219 Cardiotoxic 8 29.199 220 Cardiovascular analeptic 17 27.240 221 Catechol O methyltransferase inhibitor 12 21.302 222 Cathepsin B inhibitor 13 13.384 223 Cathepsin L inhibitor 6 24.145 224 Chemopreventive 9 33.706 225 Chemoprotective 547 20.998 226 Cholecystokinin A agonist 11 16.219 227 Cholecystokinin A antagonist 43 10.871 228 Cholecystokinin B antagonist 75 7.482 229 Cholecystokinin agonist 25 7.061 230 Cholecystokinin antagonist 175 5.266 231 Choleretic 99 18.028 232 Cholesterol esterase inhibitor 10 12.535 233 Cholinergic agonist 49 25.469 234 Cholinergic antagonist 19 12.043 235 Chymotrypsin inhibitor 3 0.956 236 Coagulant 26 13.640 237 Cocain dependency treatment 8 25.157 238 Cognition disorders treatment 1143 22.596 239 Collagenase inhibitor 87 9.113 240 Complement inhibitor 10 33.958 241 Contraceptive 112 17.022 242 Corneal wound healing stimulator 27 26.419 243 Corticosteroid-like 50 1.909 244 Cyclooxygenase 2 inhibitor 107 9.451 245 Cyclooxygenase inhibitor 141 16.773 246 Cystic fibrosis treatment 24 28.144 247 Cytokine modulator 16 32.628 248 Cytosole dipeptidase inhibitor 7 26.471 249 Cytostatic 257 20.788 250 DNA intercalator 86 10.007 251 Dermatologic 606 23.045 252 Dihydrofolate reductase inhibitor 37 5.035 253 Dihydroorotate dehydrogenase inhibitor 6 17.104 254 Dipeptidyl aminopeptidase IV inhibitor 12 15.281 255 Diuretic 398 20.390 256 Dopa decarboxylase inhibitor 6 22.931 257 Dopamine D1 agonist 27 5.018 258 Dopamine D1 antagonist 47 10.134 259 Dopamine D2 agonist 54 5.628 260 Dopamine D2 antagonist 128 9.869 261 Dopamine D3 antagonist 47 6.703 262 Dopamine D4 antagonist 103 7.230 263 Dopamine agonist 146 11.033 264 Dopamine antagonist 339 9.366 265 Dopamine autoreceptor agonist 39 5.246 266 Dopamine beta hydroxylase inhibitor 30 7.182 267 Dopamine uptake inhibitor 27 12.986 268 Elastase inhibitor 138 10.708 269 Embryotoxic 627 19.492 270 Endothelin A receptor antagonist 92 8.763 271 Endothelin B receptor antagonist 46 8.280 272 Endothelin antagonist 4 23.107 273 Endothelin receptor antagonist 228 7.703 274 Endothelin-converting enzyme inhibitor 37 12.094 275 Enkephalinase inhibitor 39 6.288 276 Erythropoietin 6 30.351 277 Estrogen agonist 133 6.218 278 Estrogen antagonist 106 9.279 279 Estrogen receptor modulator 25 5.434 280 Estrone sulfatase inhibitor 4 13.900 281 Excitatory amino acid agonist 10 16.577 282 Excitatory amino acid antagonist 51 22.078 283 Expectorant 79 18.724 284 Factor VIIa inhibitor 5 26.855 285 Factor XIIIa inhibitor 4 10.231 286 Factor Xa inhibitor 95 5.575 287 Farnesyltransferase inhibitor 139 11.101 288 GABA A receptor agonist 28 20.205 289 GABA A receptor antagonist 3 15.289 290 GABA B receptor agonist 5 18.818 291 GABA B receptor antagonist 11 10.902 292 GABA aminotransferase inhibitor 3 13.966 293 GABA receptor agonist 47 23.767 294 GABA receptor antagonist 21 16.010 295 GABA uptake inhibitor 11 12.477 296 GP IIb/IIIa receptor antagonist 266 4.622 297 Gastric antisecretory 345 16.868 298 Gastrin inhibitor 74 5.317 299 Gastrin-releasing peptide antagonist 4 5.766 300 Geranylgeranyltransferase inhibitor 4 32.004 301 Glucagon receptor antagonist 7 23.934 302 Glucocorticoid agonist 50 2.374 303 Glucocorticoid antagonist 21 8.487 304 Glucose-6-phosphate translocase inhibitor 3 16.853 305 Glutamate (mGluR) agonist 40 4.548 306 Glutamate (mGluR) antagonist 27 13.485 307 Glutamate (mGluR1) agonist 19 7.697 308 Glutamate (mGluR1) antagonist 9 6.603 309 Glutamate (mGluR1a) agonist 4 10.234 310 Glutamate (mGluR2) agonist 7 12.120 311 Glutamate (mGluR2) antagonist 10 10.567 312 Glutamate (mGluR3) agonist 11 10.413 313 Glutamate (mGluR3) antagonist 10 13.466 314 Glutamate (mGluR5) agonist 8 14.641 315 Glutamate (mGluR5) antagonist 9 25.829 316 Glutamate (mGluR5a) agonist 4 10.234 317 Glutamate (mGluR6) agonist 7 6.716 318 Glutamate (mGluR6) antagonist 4 13.360 319 Glutamate receptor agonist 96 7.078 320 Glutamate receptor antagonist 509 10.517 321 Glutamate uptake inhibitor 9 11.656 322 Glycinamide ribonucleotide formyltransferase inhibitor 12 3.646 323 Glycine receptor agonist 4 20.221 324 Growth hormone release promoting 47 5.088 325 Growth hormone secretion inhibitor 10 13.708 326 Growth stimulant 46 15.979 327 Gynecological disorders treatment 4 20.963 328 H+/K+-transporting ATPase inhibitor 128 12.096 329 HCV NS3 protease inhibitor 6 29.920 330 HCV NS3-4A protease inhibitor 3 11.074 331 HCV NS3-helicase inhibitor 4 14.644 332 HCV serine protease inhibitor 13 21.613 333 HDL-cholesterol increasing 165 21.513 334 HIV integrase inhibitor 9 31.631 335 HIV protease inhibitor 26 9.092 336 HIV-1 protease inhibitor 205 6.895 337 HMG CoA reductase inhibitor 189 3.975 338 HMG CoA synthase inhibitor 8 9.804 339 Hair growth promoter 66 14.287 340 Hematopoietic 47 16.808 341 Hematopoietic inhibitor 19 25.903 342 Hepatoprotectant 87 17.025 343 Hestagen antagonist 7 25.365 344 Hestagen-like 38 2.615 345 Histamine H1 receptor antagonist 38 17.653 346 Histamine H2 receptor agonist 5 17.298 347 Histamine H2 receptor antagonist 62 9.347 348 Histamine H3 receptor agonist 10 6.573 349 Histamine H3 receptor antagonist 28 2.002 350 Histamine agonist 24 6.697 351 Histamine antagonist 592 15.958 352 Histamine release stimulant 23 30.429 353 Histidine decarboxylase inhibitor 9 10.520 354 Hypertensive 136 19.826 355 Hypertensive, ophthalmic 12 21.638 356 Hypertermic 17 23.248 357 Hypnotic 10 33.709 358 Hypoglycemic 140 16.090 359 Hypolipemic 970 14.362 360 Hypotermic 117 25.751 361 Ileal bile acid transport inhibitor 12 14.878 362 Immunomodulator 938 26.310 363 Immunostimulant 173 23.079 364 Immunosuppressant 514 24.313 365 Immunosuppressant Cyclosporine-like 13 2.341 366 Inflammatory Bowel disease threatment 82 27.101 367 Insulin promoter 22 28.236 368 Insulin secretagoues 12 13.952 369 Interferon inducer 12 21.883 370 Interleukin 1 antagonist 78 27.939 371 Interleukin 1 beta converting enzyme inhibitor 27 6.824 372 Interleukin 6 antagonist 10 34.052 373 Interleukin 8 antagonist 31 14.947 374 Interleukin agonist 27 6.824 375 Interleukin antagonist 105 25.511 376 Irritable Bowel syndrome therapy 148 25.172 377 Kainate receptor agonist 13 10.333 378 Kainate receptor antagonist 46 11.538 379 Keratolytic 10 31.374 380 Keratoses actinic(solar) treatment 6 29.476 381 Leukopoiesis inhibitor 23 31.056 382 Leukotriene A4 hydrolase inhibitor 3 5.933 383 Leukotriene B4 antagonist 73 9.332 384 Leukotriene D4 antagonist 127 4.963 385 Leukotriene antagonist 434 11.910 386 Leukotriene synthesis inhibitor 138 13.637 387 Lipid peroxidase inhibitor 143 19.722 388 Lipoxygenase inhibitor 508 12.206 389 Liver fibrosis treatment 14 20.518 390 Luteinizing hormone-releasing hormone agonist 12 6.654 391 Luteinizing hormone-releasing hormone antagonist 51 6.512 392 Lymphocytopoiesis inhibitor 9 15.575 393 MAO inhibitor 213 15.727 394 MAO-A inhibitor 26 14.245 395 MAO-B inhibitor 24 9.000 396 Maillard reaction inhibitor 21 15.315 397 Male reproductive disfunction treatment 34 33.584 398 Mannosidase inhibitor 4 17.003 399 Matrix metalloproteinase inhibitor 61 9.959 400 Mediator release inhibitor 128 23.537 401 Melatonin agonist 26 6.492 402 Melatonin antagonist 7 28.167 403 Metabolic 9 33.018 404 Microtubule formation inhibitor 108 13.212 405 Mineralocorticoid 10 5.151 406 Miotic 38 19.793 407 Motilin-like 12 7.932 408 Mucolytic 46 15.936 409 Multiple sclerosis treatment 53 34.437 410 Muscle relaxant 333 20.046 411 Mutagenic 648 12.593 412 Mydriatic 105 9.916 413 Myocardial ischemia treatment 86 30.005 414 Myristoyl transferase inhibitor 4 4.357 415 NMDA receptor agonist 32 12.568 416 NMDA receptor antagonist 365 10.200 417 NMDA receptor glycine site agonist 4 25.164 418 NMDA receptor glycine site antagonist 24 8.818 419 NMDA receptor polyamine site activator 3 16.581 420 NMDA receptor polyamine site blocker 6 6.691 421 Narcotic antagonist 29 19.650 422 Nasal decongestant 15 21.391 423 Neuraminidase (influenza) inhibitor 35 4.908 424 Neurokinin 2 antagonist 52 8.044 425 Neurokinin 3 antagonist 5 6.597 426 Neurokinin antagonist 98 5.874 427 Neuropeptide Y antagonist 24 22.561 428 Neuropeptide antagonist 24 22.561 429 Neurotensin receptor antagonist 8 12.680 430 Neurotrophic factor 20 31.985 431 Neutral endopeptidase inhibitor 77 3.520 432 Nitric oxide donor 35 5.047 433 Nitric oxide synthase inhibitor 78 11.937 434 Non-steroidal antiinflammatory agent 9 24.060 435 Nootropic 35 28.453 436 Nucleotide metabolism regulator 146 27.504 437 O6-alkylguanine-DNA alkyltransferase inhibitor 3 6.128 438 Ophthalmic drug 301 20.710 439 Opioid agonist 117 7.729 440 Opioid antagonist 51 12.788 441 Opioid delta receptor agonist 29 6.284 442 Opioid kappa receptor agonist 60 6.966 443 Opioid mu receptor agonist 25 18.962 444 Opioid partial agonist 7 17.781 445 Ornithine decarboxylase inhibitor 33 10.971 446 Oxytocin agonist 5 22.038 447 Oxytocin antagonist 55 20.765 448 Pancreatic disorders treatment 69 21.128 449 Parathyroid hormone antagonist 4 24.061 450 Peristaltic stimulant 161 12.289 451 Phosphodiesterase I inhibitor 10 16.665 452 Phosphodiesterase III inhibitor 88 12.638 453 Phosphodiesterase IV inhibitor 223 7.723 454 Phosphodiesterase V Inhibitor 14 19.427 455 Phosphodiesterase inhibitor 344 9.042 456 Phospholipase A2 inhibitor 133 15.703 457 Phospholipase C inhibitor 10 33.182 458 Phospholipase inhibitor 142 16.370 459 Photosensitizer 17 10.747 460 Platelet activating factor antagonist 284 9.427 461 Platelet adhesion inhibitor 9 27.682 462 Platelet aggregation inhibitor 998 19.811 463 Platelet antagonist 6 25.127 464 Poly(ADP-ribose)synthethase inhibitor 6 27.728 465 Postcoital contraceptive 11 13.548 466 Potassium channel activator 176 5.135 467 Potassium channel antagonist 48 17.525 468 Progesterone antagonist 36 3.919 469 Progestin agonist 17 11.989 470 Prolactin inhibitor 17 19.414 471 Prolactin secretion inhibitor 14 13.553 472 Prolyl endopeptidase inhibitor 58 5.783 473 Prostaglandin E2 antagonist 18 10.505 474 Prostaglandin agonist 128 2.945 475 Prostaglandin antagonist 41 20.525 476 Prostate disorders treatment 257 15.067 477 Protease inhibitor 154 14.972 478 Protein kinase C inhibitor 109 16.218 479 Protocollagen prolyl hydroxylase inhibitor 21 8.211 480 Psychosexual dysfunction treatment 24 29.172 481 Psychostimulant 124 23.796 482 Psychotropic 3013 19.352 483 Purine nucleoside phosphorylase inhibitor 23 4.882 484 Purinergic P2 agonist 9 1.145 485 Purinergic P2 antagonist 12 9.478 486 Purinergic P2T antagonist 9 7.125 487 Purinergic receptor agonist 9 1.145 488 Purinergic receptor antagonist 12 9.478 489 Quisqualate antagonist 5 11.237 490 Radioprotector 155 20.048 491 Radiosensitizer 55 21.126 492 Reductant 5 7.001 493 Renal disease treatment 92 20.381 494 Renin inhibitor 231 2.446 495 Respiratory analeptic 68 20.474 496 Respiratory distress syndrome treatment 77 31.775 497 Restenosis treatment 135 21.964 498 Retinoid-like 79 2.551 499 Reverse transcriptase inhibitor 145 14.414 500 Rhinitis treatment 38 30.656 501 Ribonucleoside diphosphate reductase inhibitor 4 4.124 502 Ribonucleotide reductase inhibitor 21 13.784 503 S-adenosyl-L-homocysteine hydrolase inhibitor 12 3.508 504 S-adenosyl-L-methionine decarboxylase inhibitor 4 24.966 505 Saluretic 109 15.751 506 Saluretic, reabsorbtion inhibitor 69 10.961 507 Sclerosant 6 22.557 508 Sedative 566 23.527 509 Selectin antagonist 7 8.663 510 Septic shock treatment 230 24.918 511 Sigma receptor antagonist 89 10.390 512 Signal transduction pathways inhibitor 6 10.977 513 Skeletal muscle relaxant 297 20.120 514 Sodium channel blocker 48 24.653 515 Sodium channel blocker class Ib 6 23.493 516 Somatostatin agonist 12 4.214 517 Spasmogenic 260 19.608 518 Spasmolytic 1222 21.291 519 Spasmolytic, Papaverin-like 205 18.778 520 Spasmolytic, urinary 34 22.864 521 Spermicide 25 31.588 522 Squalene epoxidase inhibitor 22 14.662 523 Squalene synthetase inhibitor 105 6.919 524 Steroid-like 59 2.092 525 Substance P antagonist 241 5.973 526 Succinic dehydrogenase inhibitor 8 13.602 527 Sulfonylureas 4 14.052 528 Sympatholytic 44 22.617 529 TNF-alpha release inhibitor 10 29.366 530 Teratogen 420 20.140 531 Teratogen and/or embryotoxic 420 20.140 532 Thiol protease inhibitor 19 9.565 533 Thrombin inhibitor 251 5.834 534 Thrombolytic 29 22.547 535 Thromboxane antagonist 257 9.765 536 Thromboxane synthase inhibitor 127 11.135 537 Thymidine kinase inhibitor 7 27.063 538 Thymidylate synthase inhibitor 42 5.520 539 Thyroid hormone agonist 10 10.927 540 Thyroid hormone antagonist 31 13.078 541 Thyrotropin releasing hormone agonist 8 7.562 542 Topoisomerase II inhibitor 9 33.417 543 Topoisomerase inhibitor 83 14.009 544 Treponemicidal 4 13.801 545 Trypsin inhibitor 39 11.344 546 Tryptase inhibitor 11 12.545 547 Tumour necrosis factor antagonist 160 17.098 548 Tyrosine kinase inhibitor 170 14.595 549 Ulcerogenic 26 18.356 550 Uricosuric 19 28.593 551 Uridine phosphorylase inhibitor 5 10.409 552 Urinary incontinence treatment 143 21.225 553 Urokinase inhibitor 6 27.403 554 Uterine relaxant 28 13.272 555 Uterine stimulant 4 8.753 556 Vasodilator 249 22.280 557 Vasopressin 1 antagonist 20 10.328 558 Vasopressin 2 antagonist 21 3.607 559 Vasopressor 21 27.851 560 Vitamin 13 23.465 561 Vitamin D-like 106 0.798 562 Xanthine oxidase inhibitor 16 21.450 563 Xanthine-like 27 2.616 564 cAMP modulator 35 5.984 565 cAMP phosphodiesterase inhibitor 126 27.885